Réaction #2320128

Équation de réaction

magnesium dioxide

1-phenyl-4-methyl-3,4-dihydroisoquinoline

→

pure yellow crystals

Rendement 42.5%

1-phenyl-4-methylisoquinoline

Rendement 42.5%

Solvants

benzene

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture was heated
2. 2
   Températureat reflux for 16 hours
3. 3
   AutreThe magnesium dioxide was removed by vacuum filtration
4. 4
   Lavagewashed with methylene chloride
5. 5
   AutreEvaporation of the solvent

Mode opératoire

To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.

Source