Réaction #2320113

Équation de réaction

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol

trifluoroacetic acid

→

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

Solvants

CH2Cl2

Conditions de réaction

Traitement

1. 1
   Températurerefluxed for 24 hours
2. 2
   AutreThe phases were separated
3. 3
   Lavagethe organic phase was washed with two portions of 10%-Na2CO3
4. 4
   Séchagedried (MgSO4)
5. 5
   Filtrationfiltered
6. 6
   Autreevaporated to dryness

Mode opératoire

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol (1.5 g) was dissolved trifluoroacetic acid (35 ml) and refluxed for 24 hours and then CH2Cl2 (200 ml) was added. The phases were separated and then the organic phase was washed with two portions of 10%-Na2CO3, dried (MgSO4), filtered and evaporated to dryness. Yield 1.5 g. MS m/z (relative intensity, 70 eV) 351 (M+, 27), 172 (9), 92 (11), 91 (bp), 65 (21).

Source