Réaction #2298627

Équation de réaction

6-(3-thienyl)-4-chlorothieno[3,2-d]pyrimidine

6-(3-Thienyl)-4-chlorothieno[3,2-d]pyrimidine

hydrazine monohydrate

→

(6-(3-thienyl)thieno[3,2-d]pyrimidin-4-yl) hydrazine hydrochloride

Rendement 66.0%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températureat reflux for 1 hour
3. 3
   Filtrationthe solid product was collected by vacuum filtration

Mode opératoire

A suspension of 6-(3-thienyl)-4-chlorothieno[3,2-d]pyrimidine (220, 65 mg, 0.26 mmol) and hydrazine monohydrate (0.1 mL, 2.1 mmol) in ethanol (1 mL) was heated at reflux for 1 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (6-(3-thienyl)thieno[3,2-d]pyrimidin-4-yl) hydrazine hydrochloride (48 mg, 66% yield) as a white solid.

Source