Réaction #2298626

Équation de réaction

6-(3-thienyl)-3H-thieno[3,2-d]pyrimid-4-one

6-(3-Thienyl)-3H-thieno[3,2-d]pyrimid-4-one

phosphorus oxychloride

sodium bicarbonate

→

6-(3-thienyl)-4-chlorothieno[3,2-d]pyrimidine

Rendement 81.0%

Conditions de réaction

Traitement

1. 1
   Températureat reflux for 1 hour
2. 2
   Extractionextracted with ethyl acetate
3. 3
   LavageThe organic layer was washed with water
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   Autrethe solvent evaporated under reduced pressure

Mode opératoire

A solution of 6-(3-thienyl)-3H-thieno[3,2-d]pyrimid-4-one (218, 74 mg, 0.32 mmol) in phosphorus oxychloride (2 mL) under N2 was heated at reflux for 1 hour. The resulting solution was allowed to cool to room temperature, poured into a saturated aqueous solution of sodium bicarbonate to neutralize and then extracted with ethyl acetate. The organic layer was washed with water followed by saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and the solvent evaporated under reduced pressure to yield 6-(3-thienyl)-4-chlorothieno[3,2-d]pyrimidine (65 mg, 81% yield) as a yellow solid.

Source