Réaction #2298613

Équation de réaction

acetic anhydride

methyl 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

→

3-(formylamino)-4-methyl-2-thiophenecarboxylic acid methyl ester

Rendement 95.0%

Solvants

Formic acid

Conditions de réaction

Traitement

1. 1
   Températurewhile cooling in an ice bath
2. 2
   AutreThe cooling bath was removed
3. 3
   workup.ADDITIONThe reaction mixture was diluted with water (100 mL)
4. 4
   Filtrationthe solid product collected by vacuum filtration

Mode opératoire

Formic acid (53 mL) was added to acetic anhydride (53 mL) while cooling in an ice bath. Solid methyl 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester (1, 18.2 g, 0.11 mol) was added to the cold solution in small portions. The cooling bath was removed and the resulting suspension was stirred at room temperature for 4 hours. The reaction mixture was diluted with water (100 mL) and the solid product collected by vacuum filtration to yield 3-(formylamino)-4-methyl-2-thiophenecarboxylic acid methyl ester (20.2 g, 95% yield) as a white solid.

Source