Réaction #2276376

Équation de réaction

2-(2-methoxy-phenyl)-quinazolin-4-ol

phosphorus oxychloride

→

title compound

Rendement 93.0%

4-Chloro-2-(2-methoxy-phenyl)-quinazoline

Rendement 93.0%

Conditions de réaction

Traitement

1. 1
   Températureto reflux for 4.5 hours
2. 2
   ConcentrationThe orange reaction mixture was concentrated
3. 3
   workup.ADDITIONthe resulting gum was treated with ice-cold saturated sodium bicarbonate (200 mL)
4. 4
   Extractionextracted with ethyl acetate (2×200 mL)
5. 5
   Séchagedried (MgSO4)
6. 6
   Concentrationconcentrated

Mode opératoire

A solution of 2-(2-methoxy-phenyl)-quinazolin-4-ol (2.94 g, 11.65 mmol) in phosphorus oxychloride (60 mL) was heated to reflux for 4.5 hours. The orange reaction mixture was concentrated and the resulting gum was treated with ice-cold saturated sodium bicarbonate (200 mL) and extracted with ethyl acetate (2×200 mL). The organic layers were combined, dried (MgSO4) and concentrated to give the title compound as a yellow solid (2.92 g, 93%).

Source