Réaction #2275715

Équation de réaction

[(3,5-dihydroxy-pyridine-2-carbonyl)-amino]-acetic acid tert-butyl ester

trifluoroacetic acid

→

desired compound

Rendement 89.0%

[(3,5-dihydroxy-pyridine-2-carbonyl)-amino]-acetic acid

Rendement 89.0%

Solvants

CH2Cl2

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated under reduced pressure
2. 2
   FiltrationThe solid that remains is collected by filtration
3. 3
   Lavagewashed with Et2O

Mode opératoire

To a solution of [(3,5-dihydroxy-pyridine-2-carbonyl)-amino]-acetic acid tert-butyl ester, 28, (0.10 g, 0.37 mmol) in CH2Cl2 (4 mL) at room temperature is added trifluoroacetic acid (1 mL). The reaction is stirred for 16 hours at room temperature and then concentrated under reduced pressure. The solid that remains is collected by filtration, washed with Et2O to afford 0.070 g (89% yield) of the desired compound as a colorless solid. 1H NMR (250 MHz, DMSO-d6) δ ppm 10.86 (1H, br s), 9.00 (1H, t, J=6.1 Hz), 7.77 (1H, d, J=2.4 Hz), 6.69 (1H, d, J=2.4 Hz), 3.95 (1H, d, J=6.2 Hz). HPLC-MS: m/z 213 [M+H]+.

Source