Réaction #2267067

Équation de réaction

3-methoxyphenylacetone

NaBH4

→

desired product 2

Rendement 100.0%

1-(3-Methoxyphenyl)-2-propyl alcohol

Rendement 100.0%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   ExtractionIt was extracted with CHCl3 three times
2. 2
   LavageThe combined organic phase was washed with brine
3. 3
   Séchagedried over Na2SO4
4. 4
   AutreRemoval of the solvent
5. 5
   Autreafforded the crude product
6. 6
   AutrePurification of the crude product

Mode opératoire

To a solution of 3-methoxyphenylacetone (1, 1.0 g) in methanol (30 ml) was added NaBH4 (360 mg) in portions in the period of 20 min at 0° C. The resulting solution was stirred at such temperature for another 40 min. No more starting materials were detected from TLC. Ice water was added to the reaction slowly. It was extracted with CHCl3 three times. The combined organic phase was washed with brine, and dried over Na2SO4. Removal of the solvent afforded the crude product. Purification of the crude product by using a silica gel column gave the desired product 2 (1.01 g, 100%).

Source