Réaction #2254188

Équation de réaction

ethylcyanoformate

Ethylmagnesium chloride

3-(5-bromo-4-methyl-thiophen-2-yl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

→

5-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid ethyl ester

Rendement 56.8%

Solvants

THF

THF

Conditions de réaction

Traitement

1. 1
   workup.WAITAfter 40 minutes
2. 2
   Autrethe reaction is quenched with a saturated aqueous solution of NH4Cl in water
3. 3
   ExtractionThe mixture is extracted three times with MTBE
4. 4
   Séchagedried over Na2SO4
5. 5
   Concentrationconcentrated in vacuo
6. 6
   AutreThe crude product is purified on a semi-preparative HPLC

Mode opératoire

Ethylmagnesium chloride (10.9 ml, 2M in THF) is added over 30 minutes to a solution of 3-(5-bromo-4-methyl-thiophen-2-yl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole (10.0 g, Example 2, step D) in THF (15 ml) at 0° C. After 1 hour at room temperature, a solution of ethylcyanoformate (2.81 g) in THF (15 ml) is added to the reaction mixture. After 40 minutes, the reaction is quenched with a saturated aqueous solution of NH4Cl in water. The mixture is extracted three times with MTBE. The organic phases are combined, dried over Na2SO4 and concentrated in vacuo. The crude product is purified on a semi-preparative HPLC to yield 5-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid ethyl ester (5.6 g) as a yellowish oil.

Source