Réaction #2251365

Équation de réaction

sodium hydroxide

6-methyl-5-octen-2-one

sodium borohydride

methanol

→

6-methyl-5-octen-2-ol

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Autreto destroy excess sodium borohydride
2. 2
   workup.ADDITIONthe solution poured into water
3. 3
   Extractionextracted with ether
4. 4
   LavageThe combined ether extracts are washed with aqueous sodium bicarbonate, water and brine
5. 5
   Autredried
6. 6
   Autreevaporated

Mode opératoire

Six grams of 6-methyl-5-octen-2-one is added to a solution of 3.0 g. of sodium borohydride, 80 ml. of methanol and 6 ml. of 2N sodium hydroxide solution. After about two hours, acetic acid is added to destroy excess sodium borohydride and the solution poured into water and extracted with ether. The combined ether extracts are washed with aqueous sodium bicarbonate, water and brine, dried and evaporated to yield 6-methyl-5-octen-2-ol which is purified by chromatography.

Source