Réaction #2251197

Équation de réaction

methyl isothiocyanate

ethylenediamine

5-benzyl-4-chloromethyloxazole

N-(5-benzyl-4-oxazolylmethyl)ethylenediamine

→

N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]thiourea

Conditions de réaction

Mode opératoire

Reacting ethylenediamine with 5-benzyl-4-chloromethyloxazole by the procedure of Example 34, then reacting the resulting N-(5-benzyl-4-oxazolylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) and chromatographing gives N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]thiourea. Reacting this thiourea with lead cyanamide by the procedure of Example 3(b) gives N-2-((5-benzyl-4-oxazoly)methylamino)ethyl]-N'-cyano-N"-methylguanidine.

Source