Réaction #2208641

Équation de réaction

3-amino-5-methyl-2H-pyrazole

2-chloro-4-(4-methylpiperidin-1-yl)-pyrimidine

Potassium carbonate

→

title compound

Rendement 50.0%

[4-(4-Methylpiperidin-1-yl)-pyrimidin-2-yl]-(5-methyl-2H-pyrazol-3-yl)-amine

Rendement 50.0%

Solvants

BuOH

Conditions de réaction

Traitement

1. 1
   Températurethe reaction mixture was then heated
2. 2
   Températureunder reflux overnight
3. 3
   AutreThe solvent was evaporated
4. 4
   workup.DISSOLUTIONthe residue dissolved in a mixture ethanol/water (1/3, 4 mL)
5. 5
   FiltrationThe resulting suspension was filtered
6. 6
   Lavagewashed with water twice
7. 7
   Lavagerinsed with ether twice

Mode opératoire

To a solution of 2-chloro-4-(4-methylpiperidin-1-yl)-pyrimidine (prepared using a procedure similar to the one reported in Eur. J. Med. Chem., 26(7) 729(1991))(222 mg, 1.05 mmol) in BuOH (5 mL) was added 3-amino-5-methyl-2H-pyrazole (305 mg, 3.15 mmol) and the reaction mixture was then heated under reflux overnight. The solvent was evaporated and the residue dissolved in a mixture ethanol/water (1/3, 4 mL). Potassium carbonate (57 mg, 0.41 mmol) was added and the mixture was stirred at room temperature for 2 hours. The resulting suspension was filtered, washed with water twice and rinsed with ether twice to give the title compound as a white solid (143 mg, 50%): mp 193-195° C.; 1H NMR (DMSO) 67 0.91 (3H, d), 1.04 (2H, m), 1.67 (3H, m), 2.16 (3H, s), 2.83 (2H, t), 4.31 (2H, m), 6.19 (2H, m), 7.87 (1H, d), 8.80 (1H, br s), 11.71 (1H, s); IR (solid) 1627, 1579, 1541, 1498, 1417, 1388, 1322, 1246; MS 273.3(M+H)+.

Source