Réaction #220654

ord-f0f9ae53b02d437da9ccbafeb65972af

Équation de réaction

N#CCC(=O)c1cc(F)cc(F)c1
3,5-difluorobenzoyl-acetonitrile
C[C@H](N)[C@@H](Cc1ccc(Cl)cc1)c1cccc(C#N)c1.Cl
3-(4-chlorophenyl)-2(S)(3-cyanophenyl)-1(S)-methyl-propylamine hydrochloride
→
C[C@H](NC(CC#N)c1cc(F)cc(F)c1)[C@@H](Cc1ccc(Cl)cc1)c1cccc(C#N)c1
3-(1(S)-(4-Chlorobenzyl)-2(S)-((1-(3,5-difluorophenyl)-2-cyanoethyl)amino)propyl)benzonitrile

Réactifs

N#CCC(=O)c1cc(F)cc(F)c1
3,5-difluorobenzoyl-acetonitrile
C[C@H](N)[C@@H](Cc1ccc(Cl)cc1)c1cccc(C#N)c1.Cl
3-(4-chlorophenyl)-2(S)(3-cyanophenyl)-1(S)-methyl-propylamine hydrochloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreThis compound was synthesized
  2. 2
    Autrem/e=450 (M+1), 452 (M+3) (3.55 min)

Mode opératoire

This compound was synthesized according to the procedure of Example 33 from 205 mg (1.13 mmol) of 3,5-difluorobenzoyl-acetonitrile and 300 mg (0.93 mmol) of 3-(4-chlorophenyl)-2(S)(3-cyanophenyl)-1(S)-methyl-propylamine hydrochloride. LC-MS: m/e=450 (M+1), 452 (M+3) (3.55 min).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07390835B2uspto-grants-2008_06