Réaction #2196

Équation de réaction

4-chloro-4'-methylthiomethylbenzophenone

methanol

Sodium periodate

→

desired product

Rendement 93.0%

4-Chloro-4'-methylsulfinylmethylbenzophenone

Rendement 93.0%

Solvants

water

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added to this solution
2. 2
   ConcentrationThe reaction mixture was concentrated
3. 3
   workup.ADDITIONwater was added
4. 4
   ExtractionThe mixture was extracted with ethyl acetate
5. 5
   LavageThe ethyl acetate layer was washed with water
6. 6
   Séchagedried over anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONEthyl acetate was distilled off under reduced pressure
8. 8
   LavageThe residual solid was washed with n-hexane

Mode opératoire

4-chloro-4'-methylthiomethylbenzophenone (4.2 g) was added to methanol (150 ml). Sodium periodate (3.6 g) dissolved in water (20 ml), was added to this solution, and the mixture was stirred for 16 hours at room temperature. The reaction mixture was concentrated, and water was added thereto. The mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (4.1 g, melting point: 116° to 118° C., yield: 93%).

Source