Réaction #2195473

ord-043dc0a2b807409b8a6633c7a76e8f91

Équation de réaction

Oc1ccccc1
phenol
[H-].[Na+]
sodium hydride
Cl
HCl
→
c1ccc2c(c1)oc1ccccc12
Dibenzofuran

Réactifs

Oc1ccccc1
phenol
[H-].[Na+]
sodium hydride
Cl
HCl

Réactifs

Aucun

Solvants

CS(C)=O
DMSO

Conditions de réaction

Température
120°CELSIUS
Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    ExtractionThe aqueous phase is extracted with MTB ether
  2. 2
    SéchageThe organic phase is dried over sodium sulfate
  3. 3
    Autreevaporated
  4. 4
    Autrechromatographed on silica gel

Mode opératoire

The phenol 10 is dissolved in DMSO under nitrogen, a 60% sodium hydride/mineral oil suspension is added, and the mixture is warmed to 120° C. After 5 hours at this temperature, the cooled batch is added to dil. HCl solution. The aqueous phase is extracted with MTB ether. The organic phase is dried over sodium sulfate, evaporated and chromatographed on silica gel.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07514127B2uspto-grants-2009_04