Réaction #2195

Équation de réaction

4-bromomethyl-4'-chlorobenzophenone

methylmercaptan sodium

→

desired product

Rendement 83.0%

4-Chloro-4'-methylthiomethylbenzophenone

Rendement 83.0%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Températureunder reflux
2. 2
   ConcentrationThe reaction mixture was concentrated
3. 3
   Extractionextracted with ethyl acetate
4. 4
   LavageThe ethyl acetate layer was washed with water
5. 5
   Séchagedried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONEthyl acetate was distilled off under reduced pressure
7. 7
   LavageThe residual solid was washed with n-hexane

Mode opératoire

4-bromomethyl-4'-chlorobenzophenone (3.1 g) and 15% methylmercaptan-sodium aqueous solution (5.6 g) were added to methanol (150 ml), and the mixture was stirred for 30 minutes under reflux. The reaction mixture was concentrated and extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (2.3 g, melting point: 59° to 61° C., yield: 83%).

Source