Réaction #2192310

Équation de réaction

2-anilinopyrimidin-4-carbaldehyde

methyl 5-aminopentanoate hydrochloride

→

title compound

Rendement 51.0%

2-Anilino-4-(piperidin-2-on-1-ylmethyl)pyrimidine

Rendement 51.0%

Conditions de réaction

Mode opératoire

By an analogous process to Method 4, 2-anilinopyrimidin-4-carbaldehyde (Method 3; 3.24, 16.2 mmol) was treated with methyl 5-aminopentanoate hydrochloride (3.0 g, 17.9 mmol) to give the title compound (2.23 g, 51%) as a pale yellow solid. NMR: 1.85 (m, 4H), 2.5 (s, 2H), 3.4 (s, 2H), 4.58 (s, 2H), 6.63 (d, 1H), 7.05 (t, 1H), 7.3 (m, 3H), 7.62 (d, 2H), 8.34 (d, 1H); m/z 305.

Source