Réaction #219171

Équation de réaction

piperidine hydrochloride

4-methylpropiophenone

1,3-dioxolane

hydrochloric acid

→

Tolperisone Hydrochloride

Solvants

MTBE

ethyl acetate

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONa suspension of the product
2. 2
   Autreis produced
3. 3
   AutreAfter that the solid is separated from the liquid as a damp product
4. 4
   Séchagedried at 60-80° C. in the vacuum oven (200-500 mbar) over a period of 12-24 hours whereby 140 kg (81.5%) of colorless crystals
5. 5
   Autreare isolated

Mode opératoire

75 kg piperidine hydrochloride and 105 kg 4-methylpropiophenone are heated to 90° C. with 180 kg of 1,3-dioxolane and 12 kg of hydrochloric acid under a nitrogen atmosphere for 7 to 20 hours. With addition of 500 kg of ethyl acetate and 440 kg MTBE at a temperature in the range of (40-80° C.), a suspension of the product is produced. After that the solid is separated from the liquid as a damp product and then dried at 60-80° C. in the vacuum oven (200-500 mbar) over a period of 12-24 hours whereby 140 kg (81.5%) of colorless crystals are isolated.

Source