Réaction #219028

Équation de réaction

2-(3,5-dimethylphenylsulfanyl)aniline

3,5-dimethylthiophenol

2-fluoronitrobenzene

2-(3,5-dimethylphenylsulfanyl)aniline

2-aminothiazole

→

2-(3,5-Dimethylphenylsulfanyl)nitrobenzene

Rendement 78.0%

N-[2-(3,5-Dimethylphenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea

Rendement 74.0%

Conditions de réaction

Mode opératoire

2-(3,5-Dimethylphenylsulfanyl)nitrobenzene (1.01 g, 78%) was prepared from 3,5-dimethylthiophenol (0.76 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(3,5-dimethylphenylsulfanyl)aniline (0.64 g, 72%) following the general procedure B. N-[2-(3,5-Dimethylphenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (131 mg, 74%) was prepared from 2-(3,5-dimethylphenylsulfanyl)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Source