Réaction #2186225

Équation de réaction

1-(2,6-dichloro-4-trifluoromethylpheny)-5-ethoxy-4-trifluoromethylthio-1 H-pyrazole-3-carbonitrile

sulfuric acid

→

title compound

Rendement 73.0%

1-(2,6-Dichloro-4-trifluoromethylphenyl)-5-ethoxy-4-trifluoromethylthio-1H-pyrazole-3-carboxylic acid amide

Rendement 73.0%

Conditions de réaction

Traitement

1. 1
   Filtrationthe precipitate filtered off
2. 2
   Lavagewashed with water
3. 3
   Autreair-dried
4. 4
   workup.DISSOLUTIONThe crude product was dissolved in heptanes/ethyl acetate (1:1)
5. 5
   Filtrationfiltered
6. 6
   AutreThe filtrate was evaporated

Mode opératoire

A stirred mixture of 1-(2,6-dichloro-4-trifluoromethylpheny)-5-ethoxy-4-trifluoromethylthio-1 H-pyrazole-3-carbonitrile (0.55 g, 1.22 mmol) and concentrated sulfuric acid (0.55 ml) was heated at 100° C. for 3 hours. The cooled mixture was added to ice water and the precipitate filtered off, washed with water and air-dried. The crude product was dissolved in heptanes/ethyl acetate (1:1) and filtered. The filtrate was evaporated to give the title compound (0.42 g, yield 73%) as yellowish crystals, mp 161° C., 1H NMR (CDCl3): 1.32 (t, 3H, CH3), 4.68 (q, 2H, OCH2), 5.54 and 6.69 (bs, 2H, C(O)NH2), and 7.77 (s, 2H, Ar—H).

Source