Réaction #2183

Équation de réaction

2-bromo-p-chloroacetophenone

methoxythiocarbonylhydrazine

→

5-(4-chlorophenyl)-3H,6H-1,3,4-thiadiazin-2-one

Rendement 48.4%

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed overnight
2. 2
   Températurecooled
3. 3
   Filtrationfiltered
4. 4
   LavageThe light yellow solid was washed with hexane
5. 5
   Autredried

Mode opératoire

A mixture of 2-bromo-p-chloroacetophenone (9.16 g), methoxythiocarbonylhydrazine (13.0 g) and acetonitrile (75 ml) was refluxed overnight and then cooled and filtered. The light yellow solid was washed with hexane and dried yielding 5-(4-chlorophenyl)-3H,6H-1,3,4-thiadiazin-2-one (4.3 g).

Source