Réaction #2175472

ord-6c3f16ffb641496fb4a72cda0b0795cf

Équation de réaction

C[C@H]1c2cccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21.Cl
Doxycycline HCl
NNC(=O)CCCCC(=O)NN
adipic dihydrazide
→
C[C@H]1c2cccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21
Doxycycline

Réactifs

C[C@H]1c2cccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21.Cl
Doxycycline HCl
NNC(=O)CCCCC(=O)NN
adipic dihydrazide
—
dextran

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreThe mixture was loaded into a 3-ml syringe
  2. 2
    Autrefitted with a Luer plug
  3. 3
    Autrewas loaded into a second syringe
  4. 4
    AutreAn injectable formulation was formed

Mode opératoire

Doxycycline-HCl (100 mg) was finely ground with 90 mg DSS (Mw, 500,000) and 8 mg adipic dihydrazide. The mixture was loaded into a 3-ml syringe fitted with a Luer plug. Oxidized dextran solution (1 ml, Mw of 500,000; 66 mg/ml) was loaded into a second syringe. An injectable formulation was formed after connecting the syringes and performing 30 reciprocations of the syringe plungers.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08435565B2uspto-grants-2013_05