Réaction #2175470

ord-570b2c73127d4c3d8e06511895f2400f

Équation de réaction

$CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSC(=O)c3ccco3)CS[C@H]12)c1csc(N)n1.Cl$

Ceftiofur HCl

adipic acid dihydrazide

→

$CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSC(=O)c3ccco3)CS[C@H]12)c1csc(N)n1$

Ceftiofur

Réactifs

$CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSC(=O)c3ccco3)CS[C@H]12)c1csc(N)n1.Cl$

Ceftiofur HCl

adipic acid dihydrazide

—

dextran

Réactifs

Aucun

Solvants

—

reaction mixture

Conditions de réaction

Conditions détaillées

See reaction.notes.procedure_details.

Traitement

1
AutreThis syringe was connected to a second syringe
2
workup.ADDITIONThe contents of the two syringes were mixed

Mode opératoire

Ceftiofur-HCl (50 mg) and adipic acid dihydrazide (10 mg) were placed in a ml syringe. This syringe was connected to a second syringe containing 1 ml of oxidized dextran (Mw, 500,000; 85 mg/ml; 1 ml). The contents of the two syringes were mixed by making 20 reciprocations. A sample (200 μl) of the reaction mixture was transferred to a 2 ml centrifuge tube for the release experiment in PBS buffer. The release profile of the matrix appears in Table 4 below:

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08435565B2uspto-grants-2013_05