Réaction #2175439

ord-5b13de9945bb428ebfd13df5ae26d016

Équation de réaction

O=S(Cl)Cl
thionylchloride
O=C(O)CN1C(=O)c2ccccc2C1=O
compound 1a
O=C(O)CN1C(=O)c2ccccc2C1=O
2-(1,3-dioxoisoindolin-2-yl)acetic acid
→
O=C(Cl)CN1C(=O)c2ccccc2C1=O
compound 2a
O=C(Cl)CN1C(=O)c2ccccc2C1=O
2-(1,3-dioxoisoindolin-2-yl)acetic chloride

Réactifs

O=S(Cl)Cl
thionylchloride
O=C(O)CN1C(=O)c2ccccc2C1=O
compound 1a
O=C(O)CN1C(=O)c2ccccc2C1=O
2-(1,3-dioxoisoindolin-2-yl)acetic acid

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

In the (G2a) step, 2 mol of thionylchloride (SOCl2) was added to the compound 1a to produce 2-(1,3-dioxoisoindolin-2-yl)acetic chloride (compound 2a) and the unreacted thionylchloride (SOCl2) was recovered by using an aspirator.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08435480B2uspto-grants-2013_05