Réaction #216175

Équation de réaction

Indole-3-carboxylic acid

diazomethane

→

compound

1H-Indole-3-carboxylic acid, methyl ester

Solvants

ether

ethyl acetate

methanol

ether

Conditions de réaction

Traitement

1. 1
   AutreThe solvent was removed in vacuo
2. 2
   Lavageeluting with dichloromethane

Mode opératoire

Indole-3-carboxylic acid (757 mg, 4.7 mmol, 1.0 eq.) was partially dissolved in a mixture of ether, ethyl acetate and methanol. While stirring, a solution of diazomethane in ether was added until a yellow color persisted. The solvent was removed in vacuo and the remaining white solid was passed through a silica gel column, eluting with dichloromethane to give the title A compound (819 mg), m.p. 147°-149° C.

Source