Réaction #2161616

Équation de réaction

2-butanone

7-hydroxy-8-propyl-4-(trifluoromethyl)-2H-chromen-2-one

3-(4-bromobutyl)-1,5,5-trimethylimidazolidine-2,4-dione

potassium carbonate

→

title compound

Rendement 103.8%

1,5,5-trimethyl-3-[4-[2-oxo-8-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy]butyl]imidazolidine-2,4-dione

Rendement 103.8%

Solvants

water

Conditions de réaction

Traitement

1. 1
   Extractionextracted with ethyl acetate
2. 2
   LavageSubsequently, the organic layer was washed with saturated saline
3. 3
   Autredried
4. 4
   Concentrationconcentrated under vacuum
5. 5
   AutreThe obtained residue was purified

Mode opératoire

A 2-butanone (2 mL) solution of 7-hydroxy-8-propyl-4-(trifluoromethyl)-2H-chromen-2-one (30 mg, 0.11 mmol), 3-(4-bromobutyl)-1,5,5-trimethylimidazolidine-2,4-dione (30.5 mg, 0.11 mmol), and potassium carbonate (22.8 mg, 0.165 mmol) was heated and stirred overnight at 80° C. The reaction solution was added with water and extracted with ethyl acetate. Subsequently, the organic layer was washed with saturated saline, dried using anhydrous sodium sulfate, and concentrated under vacuum. The obtained residue was purified using thin-layer silica-gel chromatography (hexane:ethyl acetate=1:1), and 53.5 mg of the title compound (yield 100%) was obtained as colorless oil.

Source