Réaction #2161255

Équation de réaction

4-(trifluoromethoxy)phenyl isocyanate

ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

Solvants

THF

Conditions de réaction

Traitement

1. 1
   Autresynthesis in analogy to Example 4A step 3
2. 2
   FiltrationThe reaction mixture is filtered
3. 3
   Concentrationthe filtrate is concentrated in vacuo
4. 4
   Autrepurified chromatographically

Mode opératoire

Under argon, 1.46 g (7.21 mmol) of 4-(trifluoromethoxy)phenyl isocyanate are added to 1.22 g (3.61 mmol) of ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (synthesis in analogy to Example 4A step 3, or also according to Tetrahedron Lett. 2003, 44, 1607 and the literature cited therein) in 50 ml of THF, and the mixture is stirred at room temperature overnight. The reaction mixture is filtered and the filtrate is concentrated in vacuo and purified chromatographically.

Source