Réaction #2161253

Équation de réaction

cyclohexane ethyl acetate

potassium carbonate

iodomethane

ethyl 4-nitro-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooling
2. 2
   Filtrationthe mixture is filtered
3. 3
   Lavagethe residue is washed with dichloromethane
4. 4
   AutreThe solid obtained
5. 5
   Autreis dried in vacuo

Mode opératoire

6.80 g (36.7 mmol) of ethyl 4-nitro-1H-imidazole-2-carboxylate are dissolved in 140 ml of acetone, and 11.2 g (80.8 mmol) of potassium carbonate and 4.57 ml (73.5 mmol) of iodomethane are added. The mixture is then stirred at 60° C. for 4 h. According to TLC (cyclohexane/ethyl acetate 2:1), the starting material has been converted completely. After cooling, the mixture is filtered, the residue is washed with dichloromethane and the filtrate is freed from the solvent. The solid obtained is dried in vacuo.

Source