Réaction #2161251

Équation de réaction

ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate

hydrogen

→

Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate

Solvants

THF

Conditions de réaction

Traitement

1. 1
   FiltrationThe catalyst is filtered off
2. 2
   Concentrationthe filtrate is concentrated in vacuo
3. 3
   AutreThe concentration residue is directly used further for the next reaction

Mode opératoire

3.89 g (16.26 mmol) of ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate are dissolved in 50 ml of THF, and a spatula tip of Raney nickel is added. In a hydrogenation apparatus, the reaction mixture is hydrogenated with hydrogen at room temperature. The catalyst is filtered off and the filtrate is concentrated in vacuo. The concentration residue is directly used further for the next reaction.

Source