Réaction #2161248

Équation de réaction

ammonium formate

ethyl 1-benzyl-1H-imidazole-2-carboxylate

ammonium formate

→

Ethyl imidazole-2-carboxylate

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture is heated
2. 2
   Températureunder reflux for about 6 h
3. 3
   TempératureAfter cooling
4. 4
   Filtrationthe catalyst is filtered off
5. 5
   Concentrationthe filtrate is concentrated in vacuo
6. 6
   AutreThe product that crystallizes out during this operation
7. 7
   Autreis triturated with 80 ml of ice-water
8. 8
   Filtrationcollected by suction filtration

Mode opératoire

34.7 g (150.9 mmol) of ethyl 1-benzyl-1H-imidazole-2-carboxylate are dissolved in 1005 ml of ethanol, and 34 g of ammonium formate are added. The reaction mixture is heated under reflux for about 6 h. A total of 8 g of 10% palladium-on-carbon and 18 g of ammonium formate are thereby added in small portions. After cooling, the catalyst is filtered off and the filtrate is concentrated in vacuo. The product that crystallizes out during this operation is triturated with 80 ml of ice-water and collected by suction filtration.

Source