Réaction #216076

Équation de réaction

Octadecylamine

Glycidol

→

white solid

Rendement 95.9%

3-Octadecylamino-1,2-Dihydroxy-Propane

Rendement 95.9%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Températureunder reflux for one additional hour
2. 2
   Températurecooled to room temperature
3. 3
   Autreevaporated to dryness

Mode opératoire

Octadecylamine (18 g) was dissolved in 200 ml methanol and heated to 60° C. Glycidol (4.95 g) was added dropwise under constant stirring over one and half hours. The reaction mixture was kept under reflux for one additional hour, and then cooled to room temperature, and evaporated to dryness, resulting in 22 g white solid material. This was then recrystallized from hexane, to yield ODP, mp 81°-83° C.

Source