Réaction #214800

Équation de réaction

3-methylthiopropylamine

sodium bicarbonate

bromo-t-butyl acetate

→

N-(3-methylthiopropyl)glycine t-butyl ester

Rendement 116.9%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   AutreAfter 5 hours the ethanol was removed on a rotary evaporator
2. 2
   Autrethe residue partitioned between water and chloroform
3. 3
   SéchageThe chloroform layer was dried
4. 4
   Filtrationfiltered
5. 5
   Concentrationconcentrated

Mode opératoire

To a mixture of 3-methylthiopropylamine (30.0 g, 0.285 mol) and sodium bicarbonate (12.0 g, 0.142 mol) in 250 ml of ethanol was added dropwise bromo-t-butyl acetate (27.8 g, 0.142 mol). After 5 hours the ethanol was removed on a rotary evaporator and the residue partitioned between water and chloroform. The chloroform layer was dried, filtered and concentrated to give 36.4 g of crude N-(3-methylthiopropyl)glycine t-butyl ester as an oil.

Source