Réaction #214657

ord-cd5de87adc664514a78812db4d9ff94a

Équation de réaction

CCCCCCCCCCCCN
dodecylamine
Cc1ccccc1N1CCN(CC(O)c2ccc(O)c(C(=O)NCC(C)(C)C)c2)CC1.Cl
neopentylamine
Cc1ccccc1N1CCN(CC(O)c2ccc(O)c(C(=O)NCC(C)(C)C)c2)CC1.Cl
N-(2,2-dimethylpropyl)-2-hydroxy-5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]benzamide monohydrochloride
→
CCCCCCCCCCCCNC(=O)c1cc(C(O)CN2CCN(c3ccccc3C)CC2)ccc1O.Cl
N-dodecyl-2-hydroxy-5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]benzamide hydrochloride

Réactifs

CCCCCCCCCCCCN
dodecylamine
Cc1ccccc1N1CCN(CC(O)c2ccc(O)c(C(=O)NCC(C)(C)C)c2)CC1.Cl
neopentylamine
Cc1ccccc1N1CCN(CC(O)c2ccc(O)c(C(=O)NCC(C)(C)C)c2)CC1.Cl
N-(2,2-dimethylpropyl)-2-hydroxy-5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]benzamide monohydrochloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Following essentially the same procedure but substituting dodecylamine for the neopentylamine above results in the preparation of N-dodecyl-2-hydroxy-5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]benzamide hydrochloride.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US04255575uspto-grants-1981_03