Réaction #214454

Équation de réaction

glutaric anhydride

4-aminopyridine

→

1-(4-pyridyl)-piperidine-2,6-dione

Solvants

xylene

Conditions de réaction

Traitement

1. 1
   AutreThe starting material is prepared
2. 2
   Températureis refluxed
3. 3
   Filtrationthe solids are filtered off
4. 4
   Extractionextracted twice with 200 ml chloroform
5. 5
   Températureat reflux
6. 6
   AutreThe combined extracts are evaporated
7. 7
   Autrethe residue recrystallized twice from ethyl acetate

Mode opératoire

The starting material is prepared as follows: The mixture of 34.2 g of glutaric anhydride, 28.2 g of 4-aminopyridine and 650 ml of xylene is refluxed with stirring for 6 hours. It is allowed to cool to room temperature, the solids are filtered off and extracted twice with 200 ml chloroform at reflux. The combined extracts are evaporated and the residue recrystallized twice from ethyl acetate to yield the 1-(4-pyridyl)-piperidine-2,6-dione melting at 153°-155°.

Source