Réaction #2140523

ord-728662028a0e47228aae2dc73d79d9d2

Équation de réaction

CSC1=NC(=O)/C(=C/c2ccc3ncccc3c2)S1
2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one
N[C@@H](C(=O)O)c1ccccc1
D-phenylglycine
CCN(C(C)C)C(C)C
DIEA
→
O=C1N=C(N[C@@H](C(=O)O)c2ccccc2)S/C1=C\c1ccc2ncccc2c1
(R)-{4-oxo-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-4,5-dihydro-thiazol-2-ylamino}-phenyl-acetic acid

Réactifs

CSC1=NC(=O)/C(=C/c2ccc3ncccc3c2)S1
2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one
N[C@@H](C(=O)O)c1ccccc1
D-phenylglycine
CCN(C(C)C)C(C)C
DIEA

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, D-phenylglycine and DIEA to give (R)-{4-oxo-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-4,5-dihydro-thiazol-2-ylamino}-phenyl-acetic acid. LC-MS m/e 390 (MH+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07326786B2uspto-grants-2008_02