Réaction #214038

Équation de réaction

acetic acid anhydride

ethyl 4-piperidineacetate

→

ethyl 1-acetyl-4-piperidineacetate

Rendement 82.0%

Solvants

methylbenzene

Conditions de réaction

Traitement

1. 1
   Températurerefluxed for 3 hours
2. 2
   AutreThe reaction mixture is evaporated
3. 3
   workup.ADDITIONthe residue is diluted with water
4. 4
   ExtractionThe product is extracted with methylbenzene
5. 5
   AutreThe extract is dried
6. 6
   Filtrationfiltered
7. 7
   Autreevaporated

Mode opératoire

A mixture of 200 parts of acetic acid anhydride, 90 parts of ethyl 4-piperidineacetate and 225 parts of methylbenzene is stirred and refluxed for 3 hours. The reaction mixture is evaporated and the residue is diluted with water. The product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 92 parts (82%) of ethyl 1-acetyl-4-piperidineacetate as a residue.

Source