Réaction #2119

Équation de réaction

diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate

ethyl iodide

potassium carbonate

→

Diethyl [4-(7-ethyl-3-methylxanthin-1-yl)butyl]phosphonate

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   FiltrationThe solid was filtered off
2. 2
   Concentrationthe filtrate was concentrated under reduced pressure
3. 3
   Filtrationfiltered again
4. 4
   Autrecrystallized from diisopropyl ether

Mode opératoire

7.2 g (0.02 mol) of diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate were suspended in 100 ml of DMF, treated with 4.7 g (0.03 mol) of ethyl iodide and 4.1 g (0.03 mol) of activated potassium carbonate and heated at 60° C. for 4 hours. The solid was filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

Source