Réaction #2109

Équation de réaction

diethyl 5-hydroxypentylphosphonate

3,4-dihydropyran

pyridinium toluene-4-sulfonate

→

Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   Températureunder reflux for 16 hours
2. 2
   LavageThe solution was washed with water and saturated sodium hydrogen carbonate solution
3. 3
   Séchagedried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled in a bulb tube

Mode opératoire

A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.

Source