Réaction #2075739

Équation de réaction

2-methyl-3-nitro anisole

→

2-methyl-3-methoxyaniline

Rendement 98.0%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Autreat atmospheric pressure and room temperature
2. 2
   Autrefor 19 h
3. 3
   FiltrationThe reaction mixture was filtered through a Celite pad
4. 4
   Lavagerinsed
5. 5
   Autreevaporated to dryness

Mode opératoire

To a solution of 2-methyl-3-nitro anisole A1 (5.1 g; 30.33 mmol; requires ˜30 min to dissolve) in absolute ethanol (85 mL) was added 10% Pd/C catalyst (500 mg). The solution was hydrogenated under a hydrogen filled balloon at atmospheric pressure and room temperature for 19 h. The reaction mixture was filtered through a Celite pad, rinsed and evaporated to dryness to obtain 2-methyl-3-methoxyaniline A2 as a deep mauve oil (4.1 g; 29.81 mmol; 98% yield).

Source