Réaction #2069929

Équation de réaction

4-cyano-4′-hydroxybiphenyl

allyl bromide

potassium carbonate

2-butanone

→

4-allyloxy-4′-cyanobiphenyl

Rendement 91.3%

Solvants

Water

Conditions de réaction

Traitement

1. 1
   AutreA solution prepared
2. 2
   Températurewas refluxed for 7 hours
3. 3
   Lavagethe organic layer was washed with water
4. 4
   Séchagedried with anhydrous magnesium sulfate
5. 5
   AutreThe solvent was evaporated away
6. 6
   Autrethe resulting residue was purified through silica gel column chromatography
7. 7
   Autrefurther recrystallized from ethanol

Mode opératoire

A solution prepared by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of allyl bromide and 25 g of potassium carbonate to 250 ml of 2-butanone was refluxed for 7 hours. Water was added to the reaction solution for liquid-liquid separation, and the organic layer was washed with water and dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the resulting residue was purified through silica gel column chromatography using toluene as an eluent solvent and then further recrystallized from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

Source