Réaction #2069924

Équation de réaction

Acetic anhydride

4-isopropylaniline

→

N-Acetyl-4-isopropylaniline

Solvants

chloroform

Conditions de réaction

Traitement

1. 1
   TempératureIn the course of this, intense heating of the reaction mixture
2. 2
   workup.ADDITIONOn completion of the dropwise addition
3. 3
   ConcentrationThe reaction mixture is concentrated to dryness
4. 4
   Autrethe resulting, reddish-white solid is recrystallized from hexane

Mode opératoire

Acetic anhydride (26.0 g, 254 mmol) is slowly added dropwise to a solution of 4-isopropylaniline (17.2 g, 127 mmol) in 80 ml of chloroform. In the course of this, intense heating of the reaction mixture occurs. On completion of the dropwise addition, the mixture is stirred at room temperature for another 2 h. The reaction mixture is concentrated to dryness and the resulting, reddish-white solid is recrystallized from hexane.

Source