Réaction #2063227

Équation de réaction

2-Bromo-3-methoxy-6-nitropyridine

hydrogen

→

product

Rendement 99.0%

2-Bromo-3-methoxy-6aminopyridine

Rendement 99.0%

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   AutreThe catalyst was removed by filtration
2. 2
   Concentrationthe filtrate concentrated

Mode opératoire

2-Bromo-3-methoxy-6-nitropyridine (Desc. 5; 9.0 g, 38.6 mmol) and platinum (IV) oxide hydrate (250 mg) in ethyl acetate (250 ml) was hydrogenated at 20 psi hydrogen for 1 hour. The catalyst was removed by filtration and the filtrate concentrated to give the product as a yellow solid (7.73 g, 38.1 mmol, 99% yield).

Source