Réaction #2053488

Équation de réaction

diethyl azodicarboxylate

8-fluoro-3-iodocinnolin-4(1H)-one

3-methoxy-3-methylbutan-1-ol

triphenylphosphine

→

expected compound

8-Fluoro-3-iodo-1-(3-methoxy-3-methylbutyl)cinnolin-4(1H)-one

Solvants

THF

Conditions de réaction

Traitement

1. 1
   workup.WAITthe mixture is left
2. 2
   ConcentrationThe reaction mixture is concentrated under vacuum
3. 3
   Autrethe residue is chromatographed on silica gel, elution

Mode opératoire

A mixture of 0.72 g of 8-fluoro-3-iodocinnolin-4(1H)-one and 0.48 ml of 3-methoxy-3-methylbutan-1-ol in 20 ml of THF is cooled to 5° C., 0.97 g of triphenylphosphine is added and then 0.65 g of diethyl azodicarboxylate is slowly added, and the mixture is left stirring overnight at AT. The reaction mixture is concentrated under vacuum and the residue is chromatographed on silica gel, elution being carried out with the cyclohexane/AcOEt mixture (75/25; v/v) and then with AcOEt. The expected compound is obtained.

Source