Réaction #2045025

Équation de réaction

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester

ethylene glycol

→

37

Rendement 84.0%

6-[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-hexanoic acid methyl ester

Rendement 84.0%

Solvants

Water

Conditions de réaction

Traitement

1. 1
   Autrerose to 46° C
2. 2
   Filtrationcrude 37 was filtered
3. 3
   Autredried
4. 4
   Autrerecrystallised from toluene

Mode opératoire

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester 36 (15 g, 57 mmol) was added to ethylene glycol (50 ml) at room temperature. The reaction was exothermic and the temperature rose to 46° C. The reaction mixture was allowed to cool to room temperature and later stirred at room temperature for 16 hours. Water (150 ml) was added and crude 37 was filtered, dried and recrystallised from toluene to get pure 37 (12 g, 84%) as a white powder. M.p: 69.5-71.5° C.

Source