Réaction #2045018

Équation de réaction

(4-Isocyanato-phenoxy)-acetic acid methyl ester

ethylene glycol

→

29

Rendement 82.9%

[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester

Rendement 82.9%

Solvants

Water

Conditions de réaction

Traitement

1. 1
   Filtrationcrude 29 was filtered
2. 2
   Autredried
3. 3
   Autrepurified by column chromatography on silica gel

Mode opératoire

(4-Isocyanato-phenoxy)-acetic acid methyl ester 28 (15 g, 72.46 mmol) was added to ethylene glycol (30 ml) at room temperature. The reaction was exothermic and the temperature raised to 42° C. Later the reaction mixture was stirred at room temperature for 16 hours. Water (100 ml) was added and crude 29 was filtered, dried and purified by column chromatography on silica gel using chloroform as eluant to get pure 29 (16.17 g, 82.9%) as a off-white powder. M.p: 85.5-87.5° C.

Source