Réaction #2045010

Équation de réaction

6-(4-Acetylaminophenoxy)hexanoic acid methyl ester

6-(4-Acetylamino-phenoxy)-hexanoic acid methyl ester

hydrochloric acid

→

20

Rendement 55.6%

6-(4-Amino-phenoxy)-hexanoic acid Hydrochloride

Rendement 55.6%

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   Filtrationfiltered hot
4. 4
   Filtrationfiltered
5. 5
   Autredried

Mode opératoire

A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.

Source