Réaction #2045007

Équation de réaction

2-(4-Acetylaminophenoxy)propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

17

Rendement 98.1%

2-(4-Amino-phenoxy)-propionic acid

Rendement 98.1%

Solvants

hydrochloric acid

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   Filtrationfiltered hot
4. 4
   Filtrationfiltered
5. 5
   Autredried

Mode opératoire

A mixture of 2-(4-Acetylaminophenoxy)propionic acid methyl ester 16 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 17 (240 g, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

Source