Réaction #2028892

Équation de réaction

compound

4-[4-bromomethyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

collidine

dimethyl sulfoxide

→

desired product

Rendement 66.0%

4-[4-formyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Rendement 66.0%

Conditions de réaction

Traitement

1. 1
   AutreThe reaction solution was partitioned between ethyl acetate and water
2. 2
   Lavagethe organic solution was washed with water
3. 3
   Autredried
4. 4
   Concentrationconcentrated
5. 5
   AutreThe residue was chromatographed (1:1 hexane:ethyl acetate)

Mode opératoire

To a solution of the compound prepared in Step 1 (362 mg, 0.79 mmol) in dimethyl sulfoxide (7 mL) was added collidine (0.14 mL, 1.0 mmol). The solution was heated at 120° C. for 3 hours and then kept at overnight at room temperature. The reaction solution was partitioned between ethyl acetate and water and the organic solution was washed with water, dried and concentrated. The residue was chromatographed (1:1 hexane:ethyl acetate) to give the desired product (205 mg, 66%).

Source