Réaction #2028884

Équation de réaction

HCl

sodium methoxide

Ethyl trifluoroacetate

6-methyltetralone

→

oil

Rendement 85.1%

6-methyl-2-(trifluoroacetyl)tetralone

Rendement 85.1%

Solvants

ether

Conditions de réaction

Traitement

1. 1
   AutreThe organic layer was collected
2. 2
   Lavagewashed with brine
3. 3
   Séchagedried over MgSO4
4. 4
   Concentrationconcentrated in vacuo

Mode opératoire

Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 1N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.

Source