Réaction #2006486

Équation de réaction

compound 25

1-Benzyl-4-(2-hydroxy-ethyl)-piperidin-4-ol

charcoal

→

desired compound 26

Rendement 102.7%

4-(2-Hydroxy-ethyl)-piperidin-4-ol

Rendement 102.7%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe solution was purged three times with hydrogen
2. 2
   FiltrationThe resulting solution was then filtered on celite plug

Mode opératoire

To a solution of compound 25 (1.32 g, 5.30 mmol) in methanol (10 mL) under argon was added palladium hydroxide (20%) on activated charcoal (132 mg, 10% w/w). The solution was purged three times with hydrogen and stirred under hydrogen atmosphere at 60° C. for 4 hrs. The resulting solution was then filtered on celite plug to give desired compound 26 (790 mg, 94%) which was used as such for the next step.

Source